Monoclonal antibody purification with hydroxyapatite
نویسندگان
چکیده
منابع مشابه
Monoclonal antibody purification with hydroxyapatite.
Hydroxyapatite (HA) has been used for IgG purification since its introduction in the 1950s. Applications expanded to include IgA and IgM in the 1980s, along with elucidation of its primary binding mechanisms and the development of ceramic HA media. With the advent of recombinant monoclonal antibodies, HA was demonstrated to be effective for removal of antibody aggregates, as well as host cell p...
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ژورنال
عنوان ژورنال: New Biotechnology
سال: 2009
ISSN: 1871-6784
DOI: 10.1016/j.nbt.2009.03.017